Party Vibe

@tryptameanie 978012 wrote:

No idea my friend but most dtrugs thzt are stated as permamnet receptor inhibitors, certain MAOIs fit this bill but even though billed as permanent they reverse in around 3 weeks. This compound I know nothing about though.

thanks for that info, i took naltrexone because of the issue i had with tramadol, i just never recovered

from what ive read and people ive asked its ‘impossible’ for naltrexone to be permanent as opioid receptors are always recycling in the brain

but after 3 months of this maybe im a rarity? maybe ive got a faulty opioid system? not sure thats possible either

@tryptameanie 978014 wrote:

What has been said by others sounds true to me. For my painkiller problems I was put on methadone but natrexone is somethong I’ve never encountered.

Also, the receptors in the brain are constantly regenerated so that would indicate the correctness of their answers but if you still have no response to opiods then maybe you should ask a doctor.

yeah thats basically what people have told me. i should give it more time, its not as if its 2 years down the line, but i’ll see a doctor in the near if it still persists

2 things have been suggested as the cause 1. the state of my liver, as naltrexone is metabolised extensively in the liver, so to get bloods done. 2 after my bout with tramadol and not recovering i could have a hyper sensitive opioid system which would explain my experience with naltrexone – a change in expression of receptors which can take months apparently

thanks, and yes the second option id have to agree with, because it literally cant be permanent

the reason i mentioned the liver is because my family history, theres been auto-immune hepatitis as far back as my grandad. if i had that, which is severe liver inflammation and scarring, constant damage. naltrexone would have a hard time being metabolised and severely delayed. so i’d best get bloods to be safe

alright, ive just booked bloods weds morning, ill update this when i get the results if thats ok

thanks alot for your time dude, really appreciate it

@tryptameanie 978023 wrote:

Hey let us know how it goes and I’m here to help :).

So earlier on today i spoke with a pharmacist,

he said ‘it is not possible to permanently blockade receptors, even if naltrexone was to covalent with the receptors, eventually they would die off and new receptors would be built. if it was permanent we’d have our cure for people who misuse opiates”

so if it cant be permanent i really just gotta wait it out, and just check my liver is ok

Update: Doctor phoned to tell me my liver function tests are deranged, and with the history of AIH in my family its a big possibility now. more tests needed

So in regards to the Naltrexone, he believes it could be a ‘change in expression of receptors’ AND my liver not being able to metabolize/flush the naltrexone. A double whammy really

More tests are needed to find out if i definitely have AIH

@tryptameanie 978365 wrote:

Thanks for reporting back ud, sorry to hear about the results.

thank you man, yeah it sucks but when they get me on treatment the prognosis is excellent.

in a way it’s lucky i went for bloods, otherwise i could of carried on unbeknown my liver was comprised