TBH the only people who could confirm that would be the specialists; I think that bit of the hospital is called hepatology. There may well be a limit to what research they can actually do whilst your liver remains inside you – however if several medical sources have said it is impossible for the opiate receptors in the brain to become permanenly blocked I would be inclined to believe them.
According to this American medical source Naltrexone is not good for the liver either (a “black box” warning means just that, text in a black box on the drugs info sheet that doctors and other medical professionals should take note of).
If you are taking it and suddenly feel worse it is best to call 111 (if they think you are at risk the Ambulance will turn up and take you to hospital)
Oral Naltrexone Black-Box Warning
Naltrexone has the capacity to cause hepatocellular injury when given in excessive doses.
Naltrexone is contraindicated in acute hepatitis or liver failure, and its use in patients with active liver disease must be carefully considered in light of its hepatotoxic effects.
The margin of separation between the apparently safe dose of naltrexone and the dose causing hepatic injury appears to be only fivefold or less. Naltrexone does not appear to be a hepatotoxin at the recommended doses.
Patients should be warned of the risk of hepatic injury and advised to stop the use of naltrexone and seek medical attention if they experience symptoms of acute hepatitis.
Chapter 4?Oral Naltrexone – Incorporating Alcohol Pharmacotherapies Into Medical Practice – NCBI Bookshelf
