(Recruiting) What are the effects of nootropics or ‘smart drugs’ on executive perform Hi folks. I'm a masters student at Goldsmith's College London, studying for their MSc in Foundations in Clinical Psychology course.
I'm interested in researching the effects of 'smart drugs' or nootropics on cognitive performance; particularly the cognitive effects of modafinil.
The study would involve you coming in Goldsmiths (if you are in or near South London or London) and completing a short computerised task. It doesn't take too long and is quite fun really (for an experiment!).
If you are either prescribed modafinil, or self-administer it, I'd love to hear from you. 'Executive performance' concerns the day-to-day 'organising' aspect of our selves. So planning, organising, prioritising, deliberating, decision-making - all the higher-level stuff.
For the more dilligent folk among you who like to verify matters, my dissertation supervisor is Ashok Jansari, who works at Goldsmiths as a lecturer. You can find his webpage at http://www.gold.ac.uk/psychology/sta.../jansariashok/ or indeed contact him at a.jansari@gold.ac.uk if you wanted to confirm any of this.
My research is still in it's early stages, but it'd be great to get names down so I could contact you nearer the time and we can get some real results here. Whilst modafinil and others like it are no doubt enjoyed by many cognitive enthusiasts, no one is entirely sure how modafinil works; the 'mechanism of action', if you will. Hopefully my research would help break this down, paving the way for a greater understanding on the neuropsychological and cognitive effects of these substances, and how in society perhaps they may be optimally used.
If you're still reading, please get in touch. Probably best to email me - jsteadman22@gmail.com, with 'modafinil study' in the subject title.
I'll be happy to answer any questions you may have about either the study or about modafinil and others like it in general.
Otherwise, thanks, and hopefully I'll hear from you soon!
Jack Steadman (masters student, Goldsmith's College).
Ketamine to treat depression! Sorry if this article has been posted before but it's new to me!
New types of drugs for schizophrenia, depression and other psychiatric disorders are few and far between—and a number of companies have scaled back or dropped development of this class of pharmaceuticals. One exception stands out. Ketamine, the anesthetic and illegal club drug, is now being repurposed as the first rapid-acting antidepressant drug and has been lauded as possibly the biggest advance in the treatment of depression in 50 years.
A few trials by large pharma outfits are now underway on a new, purportedly improved and, of course, more profitable variant of ketamine, which in its current generic drug form does not make pharmaceutical marketing departments salivate.
Some physicians have decided they simply can’t wait for the lengthy protocols of the drug approval process to be sorted out. They have read about experimental trials in which a low-dose, slow-infusion of ketamine seems to produce what no Prozac-like pill can achieve, lifting the black cloud in hours, not weeks.
With nothing to offer desperate, sometimes suicidal patients, physicians have decided against waiting for an expensive, ketamine lookalike to arrive and have started writing scripts for the plain, vanilla generic version that has been used for decades as an anesthetic. Ketamine, it seems, has captivated a bunch of white coats with the same grassroots energy that has propelled the medical marijuana movement.
No formal tally of off-label ketamine prescriptions has been made. But Carlos Zarate of the National Institute of Mental Health, a leader in researching ketamine for depression, receives numerous e-mails from physicians and patients. “It’s being used in many states,” Zarate says. “I know of [people in] California, New Jersey, Pennsylvania, New York, Texas Florida and around the world, Australia, Germany, the U.K.”
Physicians are allowed to prescribe drugs off-label—in other words, uses for which they have not received approval from a regulatory agency. The practice is widespread: in fact, ketamine itself is often administered for chronic pain, a use never approved by the U.S. Food and Drug Administration.
Legalities aside, not every physician thinks ketamine has met the required thresholds of safety and efficacy to become a mainstay of a walk-in clinic. “Clearly, the use of ketamine for treatment-resistant depression is not ready for prime time,” says Caleb Alexander, a physician who is a professor of epidemiology at Johns Hopkins University and co-director of the Johns Hopkins Center for Drug Safety and Effectiveness. “We have remarkably little solid scientific evidence to support its use in nonexperimental settings, that is to say, to support its use beyond research settings.”
Ketamine has a well-known side effect of inducing a trancelike state that club aesthetes dub the “K hole”—the reason it is known in clinical terminology as a “dissociative” anesthetic. Some users get sucked into the vortex spun by Special K, Vitamin K, “jet,” “special L.A. coke,” “K,” or one of the drug’s other monikers, The physician and neuroscientist John Lilly, known for his work on dolphin communication, almost drowned under the influence while immersed in his own invention, the sensory deprivation tank and had to resuscitated by his wife. Undeterred, Lilly continued binging, at one point injecting himself almost hourly for three weeks. Others haven’t been as lucky and have succumbed fatally to what Lilly’s wife called “the seduction of K.”
In the low doses administered in off-label clinics, side effects are rare or mild. “If I closed my eyes, images would present themselves like the opening credits of Dr. Who, with a tunnel of light,” says one patient.” Even so, a prospective patient must be carefully screened and turned away if there is any history of psychotic episodes.
In prescribing ketamine for depression, clinicians take it upon themselves to determine proper treatment protocols through trial and error, either by consulting colleagues or reading the methods sections of scientific papers that report the results of preliminary experimental trials not intended to evaluate the drug for clinical use. The risks are worth taking, say some psychiatrists, particularly if a patient has tried psychotherapy and one antidepressant after another with poor results—and any mention of electroconvulsive therapy produces a look of abject terror.
“I have patients who will try anything that is reasonably safe, says David Feifel, the physician who heads Adult Psychiatric Services at the University of California, San Diego, Medical Center. Feifel read the major study by Zarate in 2006 and decided to put in place one of the first clinical programs anywhere for ketamine therapy. After receiving approval from the hospital’s pharmacy and therapeutic committee, Feifel and his team began providing ketamine therapy on a routine basis in 2011. So far, 50 people with depression that did not respond to other treatments have been willing to pay out of pocket for the infusions. As many as three times that number, some from outside the U.S., have made inquiries.
Feifel shared some e-mails: “So many days I wake up and want to die, but not today,” wrote one patient after the therapy. “Thank you so much for this day of hope and contentment. It was the most beautiful day I can remember. I was a new person today and I’m looking forward to tomorrow, which is something I never say.” Another wrote: “I wanted to go out to eat last night and go for a walk today—both things I haven’t wanted to do for years.”
Feifel estimates that seven out of 10 patients have improved, a substantially higher number than respond to Prozac and other conventional antidepressants and a rate comparable to reports in experimental studies. Side effects have been minimal—and the high from the drug, no problem. “If anything, the patients enjoy that,” Feifel says.
Feifel does not see himself in the role of proselytizer. Whether ketamine becomes a depression breakthrough depends on overcoming treatment effects that often last just a few weeks, even with multiple infusions. “This is in my opinion the biggest challenge, whether this is really going be a game changer for depression or a limited tool is if we can figure out how to make this a durable benefit,” he says.
Feifel always lays out multiple treatment options tailored to a particular patient, not just ketamine alone. He might, for instance, try to disabuse patients of misconceptions about the dangers of electroconvulsive therapy. The hospital is also exploring other new approaches: transcranial magnetic stimulation, a magnetic field trained on a brain area affected by depression; and treatment with scopolamine, another anesthetic that may possibly offer patients quick mood relief.
Off-label prescribing of ketamine does not usually take place at major university hospitals like U.C. San Diego Medical Center but, rather, in small clinics, some of which appear to be largely devoted to dispensing the drug. “There’s nothing else they have to offer really,” Feifel says. That one-track approach has the drawback of possibly leaving a patient who doesn’t respond to ketamine feeling even more desperate.
Read part 2 about patients with major depression who pay thousands of dollars of uncovered medical expenses for ketamine treatment at small clinics and physicians’ offices.
From Club to Clinic: Physicians Push Off-Label Ketamine as Rapid Depression Treatment, Part 1 | Talking back, Scientific American Blog Network
I LOVE KETAMINE Addicted To Ketamine?
Is it really possible?
Having Ketamine around me and my friends over the last 3years end having used K to knumb my unhappy existance as a depressent nearly everyday... I do believe I am. I don't drink, dont smoke and don't actually enjoy many other drugs. I suffer from BDD and OCD and get social anxiety... so as anyone could imagine the drug has helped me through some lonely times and places... mostly being the four walls of my bedroom. Although I'm trying to get off this addiction and help myself in all the areas (above) I need too... this drug still calls me everyday.
I don't do it everyday anymore but everyday if it was there I'ld do it all until It was gone and I do actually really really want it. I love Ketamine but at the same time hate it for what it has created. I look at some of my closest friends and they too are addict, supressed and trapped in the supposably non-harmful substance.
The sad thing is I love Ketamine and I know I'm not alone!
x x x x
Fully Decentralized Market Opens After Raids I read a few months ago about a project called DarkMarket that had been started after Silk Road 1 had been taken down: Inside the 'DarkMarket' Prototype, a Silk Road the FBI Can Never Seize | WIRED and now it looks like the vision has been realized by a new open-source project that's sprung up.
The Next Major Dark Net Market ? OpenBazaar ? Is Supposedly Untouchable By Police - Business Insider
Focus Presents: Wobs (Focus, OC)
Focus Presents: Wobs (Focus)
+ Evan Casey & Justin Campbell
Tuesday 5th August 2014
Get on the RSVP List here Focus OC - RSVP List (Orange County's #1 House Club)
Focus Located @
4253 Martingale Way
Newport Beach, CA 92660
Wobs is headlining this Tuesday at Focus. Get a taste of what's in store
https://soundcloud.com/musicis4lovers/hometown-heroes-wobs
Facebook Event - https://www.facebook.com/events/348281925319306/
If you have a Membership, this Tuesday you will have a complimentary +1
P.S. We've got some big plans for future Tuesdays :) Stay tuned for the good news!
More info on the club - Focus Tuesdays @ TAPAS Newport Beach - Orange County's Number 1 House Club
Purchase tickets / Monthly Membership -
Focus - Presale Tickets
Download the mixes recorded live at the club -
Live At Focus - Live House Music recordings from Focus in Orange County
52 yr old newbie My Due to my recent long career in the military I was unable to 'dabble' in certain things! We are tested randomly approx twice a year sometimes more. Now I'm 'free' I can experiment:smile:. My first 'taste' was with a 36 yr old experienced user who introduced me to this amazing new world. We had the most amazing sex in the few months before she 'drugged' me. (That's not fair because I was very willing!).
My first experience was when she brought some coke to one of our weekend hotel meets. I had a couple of lines before we went for a lunchtime drink. The conversation in the pub was much more open and I was feeling very confident and I could tell she was as well. Back to the room and a few more lines... Unbelievable! A marathon session followed :-) I won't go into detail but can if u want? Haha. Just pm me :wink:
Our next weekend she brought some ecstasy pills. We had a meal and a few drinks in the hotel bar and we both popped a pill mid-meal (her advice). Anyway, half hour after the meal we were sat chatting and FUCKINHELL! Boom. What a fantastic feeling, she started giggling and said...your eyes! You're coming up ain't ya? I really can't begin to explain the beautiful feelings I had, she wanted to go outside for a smoke so I went along. It was a very pleasant summers night, we walked around the hotel. I noticed the street lights looked fantastic, I was buzzing, laughing, smiling. I clearly remember walking along with my hands in the air and shouting. 'I'm free look at the colours'. The events in our room after were incredible...
I have to disappear for a bit now but will come back and tell you more of our 18 month relationship. I will be requesting some advice and guidance on certain substances and hope to share your knowledge to help me with some decisions about the future.
Regards.....Michael x
FBI Agent Was Silk Road Mod The people running these markets seem to be pretty stupid. They manage to set up a hidden site but then hire an FBI agent as a site mod. TOR may well be secure but as always, the problem is between the keyboard and the monitor.
US Attorney?s office: Whoops, Silk Road 2.0 hired a fed [Updated] | Ars Technica
Anyone Here Tried PCP? PCP came up in another thread and I wondered if anyone here had used it. It's a dissasociative which seems similar in it's action, but not structure, to ketamine and is also restircted to veterinary use.
From what I've read, I don't understand why this has never made it's way across the ocean. The precursors are here, even if they weren't China would be willing to ship them or the finished product, and I can't believe for 1 second their aren't enough idiots in the UK/ EU that would pay good money for it.
looking for girls with a dick Hi ppl i am looking for a girl that has a dick if you have one let me know on kik, snapchat or skype
Kik: johnathan1104
Snapchat: johnnybou1104
skype: johnnyboy1104@hotmail.com
We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.
You can revoke your consent any time using the Revoke consent button.
