5HTP and MDMA / Ecstasy / MDA

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5HTP and MDMA / Ecstasy / MDA

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August 25, 2015 at 11:34 am #701730
zdarlight420
Hi — Recently SWIM started taking 5HTP as a supplement, about 100mg to 200mg a day. SWIM would like to know is it safe to take 5HTP and MDMA at the same time / on the same days? SWIM has heard a few different things, such as taking 5HTP before MDMA can ‘ruin’ the experience. SWIM is also concerned that taking them at the same time might risk serotonin syndrome? If SWIM would like to continue taking 5HTP and MDMA, should SWIM not take 5HTP on the days SWIM takes MDMA? So stop taking 5HTP in the morning, take MDMA at night, take 5HTP the next day? Or would it be better to skip taking 5HTP up to one or two days before taking MDMA? Does anybody else have any experience with taking 5HTP and MDMA / XTC / MDA? Thank-you for the advice.
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August 25, 2015 at 7:01 pm

#975533
Digital Buddha

@digital-buddha

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5HTP is usually used by rollers as a recovery aid from MDMA sessions

doubt you’d get serotonin syndrome

idk what to tell you about the ‘ruin’ the experience bit
August 26, 2015 at 1:27 pm

#975535
tryptameanie

@tryptameanie

Participant
%-HTP, 5-hydroxy-tryptophan is seratonin. Never heard of any problems and I know a few people who use that as well as MDMA and other seratonin releasers.
August 26, 2015 at 3:05 pm

#975532
cozmic

@cozmic

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Should be no problem. I’d keep em for the comedown/following week though
August 27, 2015 at 12:17 am

#975534
Digital Buddha

@digital-buddha

Participant
@cozmic 969562 wrote:

Should be no problem. I’d keep em for the comedown/following week though

yep this is where they shine
August 27, 2015 at 11:50 am

#975537
zdarlight420

@zdarlight420

Member
Just posting this here, a helpful reply I received to this same thread on another forum for anybody who is interested;

“5-HTP and MDMA is potentially a risk for serotonin syndrome but I’m not sure how likely that is. It’s advised to avoid 5-HTP 12 hours before and after dosing MDxx.

What is more certain though is that although 5-HTP may increase serotonin in the brain, it is actually downregulating your serotonin receptors… This means when you do take MDMA, the serotonin it releases is not gonna be felt by your receptors as much, you are effectively increasing your tolerance to MDMA in a way. As far as what is understood about it would suggest anyway, and plenty of anecdotal reports.

5-HTP is best used in the 3-5 days after MDMA use, 100mg before bed, as a simple ‘safety net’ to make sure you are getting more serotonin up there for your brain to replenish. There are likely more factors involved in MDMA induced depression / anxiety or neurotoxicity than serotonin depletion alone. It is no replacement for using tested MDMA, infrequently and responsibly, with a proper vitamin/antioxidant pre/post-load regimen.

It’s also worth noting that it’s unknown how well 5-HTP makes it to the brain, and 400mg of EGCG (green tea extract) taken with the 5-HTP might be needed to aid its ability to get there.

Unfortunately a lot of the science around serotonin/5-HTP/MDMA etc is not very solid… “
August 31, 2015 at 5:58 pm

#975536
Mystic

@mysticgirls69

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The only thing that really alters sera toning levels permanently are taking the wrong SSRI’s.

Either is fine to use with the exact matching criteria you’ve noted.
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