How Cannabis Oil Works to Kill Cancer Cells and its benefits to our health . How Cannabis Oil Works to Kill Cancer Cells :
First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide(a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
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Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of CBD and THC, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for profound healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for its matched exocannabinoid activator. This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids are therapeutic. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
Dosage Information: How to take cannabis oil
For most people it takes about 60 grams/ml of cannabis oil to kill most cancers. For the average person it will take about 90 days to ingest the full 60 gram/ml treatment of cannabis oil. It is important to remember that the 60 gram/ml 90 day treatment protocol is just a recommendation and starting point. It can take some people a longer time to finish their treatment.
People should start by orally ingesting three doses of cannabis oil per day. For the first week each dose should be the size of a half grain of white rice. After the oil has been taken for a week, start to double the dose. The dose should be doubled every four days until 1 gram/ml per day is ingested. Most people to get to the point where they can ingest 1 gram/ml per day in about 30-35 days. Once ingesting one gram/ml of oil per day is achieved, dosage should continue at that rate until the cancer is gone. Some people have however increased each of their daily doses to 2grams/ml or more.
Since the starting doses of oil are so small it is very easy for cannabis oil to be dosed out of an oral syringe right into empty pill capsules. This allows for the dosing of the cannabis oil to be very consistent and precise for beginners or children just starting the cannabis oil treatment. Precise dosage is important so that the "high" side effect can be avoided as much as possible. Oral syringes also make it very easy to store your cannabis oil discreetly.
Dosing cannabis oil from Oral syringes into empty pill capsules will also allow for a patient/care-giver to dose out the cannabis oil treatment for many days or even weeks in advance. This makes it easy for a patient to keep track of how much oil that they are taking and when they take it. It also makes it easy to add the cannabis oil treatment to any other oral medication regimen that a patient might be on. Cureyourowncancer.org has made it easy for you to get your oral syringes and empty pill capsules by offering them to you in our online store. As a special offer for reading this use discount code: TAKEoff5 to get a 5% discount off of any syringes, pill capsules or apparel you order through the our online store.
for more questions and how to get your own kindly pm me thanks
email:ccogkushfungus@outlook.com
Viagra. Where to keep it when out and about? I'm looking for a more secure to carry my viagra when out and about. I have the pill fob but have been questioned or caught too many times with that damn thing.
Anyone have a better solution? Thanks
Prominent US Senators and Mayors Outed as Members of the KKK by Anonymous Fucking hell, some have some serious explaining to do :yakk:
Several prominent US Senators and mayors have been outed as members of the Ku Klux Klan (KKK) and other racist groups by the hacktivist collective Anonymous, and the group hints that more politicians and public figures will be named in the near future.
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US Senators and Mayors Outed as members of the KKK
Need speed alternative Sup guys, newbie here.
Basically, the story goes like this. There's gonna be a really sick rave this friday, and it's gonna be till 6AM. My girlfriend is coming from another city and i have to meet her at 8AM. Im sick and tired of all the drugs (especially amphetamines and MDMA with their comedowns and wierd after effects) other than weed(which tbh I don't even consider a drug)but I need to stay awake and be energetic. Is there any healthier alternatives? Cause I'd like to stay awake and energetic the 2nd day too.
Sorry if reading this wasn't very pleasant for you, english isn't my 1st language.
DIPIPANONE CYCLIZINE Hi, i am looking for a prescribed drug for a friend called DIPIPANONE CYCLIZINE. He has been taking them for sometime but recently had his prescription stopped. He is willing to pay and travel anywhere in the uk. Please contact him if any one can help 07724944621 thank you
Sassafras (vs MDMA/Molly) What's up all? New user on the forums, experienced user with MDMA.
For the most part, in my area, there's shitty "Molly". Spent a lot of time in Miami where I was able to get much better drugs for much less price.
Anyway, found someone who sells Sassafras by the gram. 1 gram for $100 so not a bad deal.
I'm wondering what the difference is, experience wise, between this and just MDMA or a Molly?
From what I've gathered - sass has more of a body high than a head rush, really smooth. It takes a little longer to start working, which can make you nervous that it's bunk, but it's that much better when it hits.
Which would be ideal. I take drugs to feel good obviously, but as I mostly do it a techno/deep house shows, it's all about feeling good and dancing my ass off. So if this can eliminate some of the head rush and give me more of a body high - bingo!
Usually with MDMA/Molly, I feel great but my body is a bit "dead". I've taken Speed to overcome the "body is shut down-ness" and be able to dance my ass off while still feeling good. Unfortunately, this is only when I travel somewhere else as Speed isn't really around at home.
Anyway - anyone have experience with Sass? Talk to me! Thanks in advance.
Pinned
Best pet? I have two cats and they're quality little animals. Absolute characters! Whats the best pet to have? You decide!!! :love:
Edit - Balls! I was gonna do a poll but fucked it right up.:crazy_diz12…45
*SUPER LONG* DXM Durations So, two years ago, I had never been on any prescription mood stabilizers, or other drugs of that sort. I tried DXM Polisterix and DXM Hydrobromide recreationally, and the durations NEVER lasted any more than 12-14 hours. Then, I started taking Bupropion XL 300mg daily for about a year. I tried DXM HBr while on Bupropion, and that was a huge mistake. I took too much, and stayed too high to even get out of bed for 3 days, and remained high (and barely able to get out of bed) for another 36 hours or so. I assumed it was because of an interaction between Bupropion and the DXM (ex: 1, 2), and never took them together again. Three months ago I stopped taking the Bupropion daily, and two weeks ago, I decided to try DXM Polisterix again (w/ daily Dexamphetamine/Amphetamine XR 30mg, Temazepam 15mg, and an occasional Toradol 10mg), seeing as how the Bupropion is definitely out of my system by now, but I was not able to get out of bed (too fucked up) for 4 days AGAIN. Has anyone had a similar experience with Bupropion and DXM? And is it possible that the Bupropion permanently fucked my CYP2D6 enzymes or something? Why would this happen???12
A nuclear dream come true…… Currently in the mood as to wishing the entirety of the human race would be killed from nuclear war. FUCK LIFE AND FUCK EVERYONE.
London Meetup looking to make a few friends share a few spliffs.
holland park area today!!
if you smell weed don't be shy to approach me.
I'm very noticeable for someone not that big
vbulletin.com has been properly hacked Details in this very long thread. I'm on page 5 only but indications are they got data and exploited a weakness in vbulletin 5.
https://theadminzone.com/threads/vbulletin-com-forums-hacked.136961/
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