DE : How i became a smoker and how i quit Written by a friend of mine from Germany who runs the Mastodon instance I use, good info about why folk start in the first place, e-cigs and dealing with addiction if you want to stop..
https://medium.com/@milanihl/how-i-became-a-smoker-and-how-i-quit-7fd89e4d98db
My name is Novi! ^_^ Hey!!! My name is Novi! I have been producing music for a a few years and am honestly trying my best to get my name out there. If you have time and want some cool party music check out my animated Soundcloud account at www.soundcloud.com/novithedj and please follow/like/comment if you enjoy anything. Thank you for reading and I hope you are able to check out my page! Much love everyone! :)
Open source lab hardware: €100 digital microscope Uses an RPI, off the shelf components/assemblies easily available across Europe and 3D printed components (if you do not have your own 3d printer they are found at hackspaces and even libraries nowadays)
This design is geared towards needs of biologists and isn't a beginners project its within the capabilities of a hackerspace or a high school Sixth Form / the first years of University..
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002702
https://hackaday.io/project/5059-flypi-cheap-microscopeexperimental-setup
UK : East : Over 39g of A-PVP was seized at 2016 Latitude Festival TBH it might not be a bad thing the cops seized it - Latitude is full of young teenagers and family groups; although I don't think its "deadly" as such I believe its a very long acting stimulant and can make people quite psychotic.
Also looking at the very small amounts seized or recorded for any other drugs its either the case that Latitude has become even more of a sixth-form festival that people attend with their parents full of entire families of straightedge hipsters; or that the cops are actually being sensible and only stopping the really nasty drugs.
Probably the answer is halfway between the two.
NB: the info below is for the 2016 event, not this years. Neither the cops nor the Press have released any crime reports for this year; I don't think anything serious did happen but the news blackout is unusual as if it really was a zero crime (or very low incident count) event surely they'd want to publicise this?
UK : Warning from the Loop : "Anonymous" logo pills with pentylone identified at the Kendall Calling festival in the North of England; making people quite ill and keeping the paramedics busy. (Pentylone is a long lasting cathinone and that is a gross overdose)
https://twitter.com/WeAreTheLoopUK/status/890947779631210496
FDA lowering nicotine in Tobacco
So if those goes through, granted that it won't get going till 2021 or 2022, but where would one go for quality tobacco on this firmament? Which countries have the best tobacco is what I'm asking.
Link to last page instead of first page I've noticed that when I press a link I always end up at page 1. It would be nice if the link goes to the last page because that's usually where the last post is ???
How Cannabis Oil Works to Kill Cancer Cells First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If endogenous ceramide(a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell is strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of CBD and THC, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for profound healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for its matched exocannabinoid activator. This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids are therapeutic. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
Dosage Information: How to take cannabis oil
For most people it takes about 60 grams/ml of cannabis oil to kill most cancers. For the average person it will take about 90 days to ingest the full 60 gram/ml treatment of cannabis oil. It is important to remember that the 60 gram/ml 90 day treatment protocol is just a recommendation and starting point. It can take some people a longer time to finish their treatment.
People should start by orally ingesting three doses of cannabis oil per day. For the first week each dose should be the size of a half grain of white rice. After the oil has been taken for a week, start to double the dose. The dose should be doubled every four days until 1 gram/ml per day is ingested. Most people to get to the point where they can ingest 1 gram/ml per day in about 30-35 days. Once ingesting one gram/ml of oil per day is achieved, dosage should continue at that rate until the cancer is gone. Some people have however increased each of their daily doses to 2grams/ml or more.
Since the starting doses of oil are so small it is very easy for cannabis oil to be dosed out of an oral syringe right into empty pill capsules. This allows for the dosing of the cannabis oil to be very consistent and precise for beginners or children just starting the cannabis oil treatment. Precise dosage is important so that the “high” side effect can be avoided as much as possible. Oral syringes also make it very easy to store your cannabis oil discreetly.
Dosing cannabis oil from Oral syringes into empty pill capsules will also allow for a patient/care-giver to dose out the cannabis oil treatment for many days or even weeks in advance. This makes it easy for a patient to keep track of how much oil that they are taking and when they take it. It also makes it easy to add the cannabis oil treatment to any other oral medication regimen that a patient might be on.
BE : warning that xtc pills twice as strong as they were 10 years ago The article below is from the Belgian Drugs early warning system. It confirms (without excessive scaremongering too) that the MDMA pills are twice as strong as those of 10 years ago (in 2006/7 there was actually a rise in pill quality in Europe) and warns against both excessive use and combination of alcohol, also pointing out quite correctly that comedowns and medium term health issues can get way worse overdoing it (rather than simply the risk of just dropping dead)
http://www.nieuwsblad.be/cnt/dmf20170718_02977662
UK : East : Cops, volunteer Ambulance service use "illegal rave" for training This of course wasn't a real rave/hall party, if you look in the photos of the news articles everyone there is way too old (the frightwig though isn't too far off some of the fashions I have seen :D)
On a serious note the Emergency Services regularly do hold exercises like this which is by and large a good thing, and its perfectly normal for them to try and base them on real life scenarios.
Alas it is not unusual for violence to break out at some of the raves/hall parties held in this region in recent times; nothing major compared to London or other big cities but still requiring investigation and treatment. As well as freakouts and OD's from NPS or party drugs, all of this has happened here in recent years.
Also in many rural areas the St Johns volunteers (who are well trained) can actually get to a remote location quicker than the main Ambulance service due to road congestion, local knowledge and often lack of available vehicles at Eastamb (who are already dealing with the casualties from the licensed premises..)
http://www.lowestoftjournal.co.uk/news/st-john-ambulance-holds-casualty-simulation-exercise-in-lowestoft-1-4956962
Horror trip from shrooms Hi, has anyone else had a horror trip from shrooms? "A friend of mine" saw faces coming out of the sand at the beach all around him and started walking out into the water to drown himself because he couldnt handle it. Did anyone have similar experience?12
UK : Govt finally abandon abstinence policies, shift more towards harm reduction Better than what went before; and already happening in my own town with the Police now referring less dangerous offenders to rehab treatment rather than only criminal penalties although something that should have happened years ago and will require proper funding to be effective..
https://www.theguardian.com/politics/2017/jul/14/chemsex-drugs-former-legal-highs-targeted-home-office
Mephedrone 4mmc meow meow mexedrone Are people still buying mephedrone or is there a better replacement
Keep hearing about mexedrone or is mephedrone still the preferred choice over all the replacements that keep coming out
Can i Get Your Help For a Sec? im looking to start a line of sexual wellness products..
my friend told me this was a good place to got some good feedback.
if it isnt too much could you fill out the survey i made.
Thank you.. https://www.questionpro.com/a/TakeSurvey?id=5690474
We use cookies to ensure that we give you the best experience on our website. If you continue to use this site we will assume that you are happy with it.
You can revoke your consent any time using the Revoke consent button.
